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European Medical Journal Oncology & Haematology Updates Версия для печати Отправить на e-mail
27.05.2015
 

 

Hello and welcome to another edition of the EMJ Oncologynewsletter, your trusted source for the latest news and developments in the closely affiliated fields of oncology and haematology. Inside you will find an abundance of updates from the cutting edge of both disciplines, including a story which details the discovery of a heritable gene mutation that can predict an individual’s susceptibility to leukaemia, as well as a report on the prevalence of malignant melanoma in the elderly. We are also drawing closer to this year’s EHA and ECC congresses, both to take place in Vienna, Austria, and EMJ is set to report on each of these in the coming months. In the meantime, however, we have included a summary of some of this year’s other major events, such as the International Symposium on Critical Bleeding in Denmark. We hope that you enjoy this newsletter, and wish you all the best for the coming months!

 
Articles
 
K Sap, P Van Trappen
In this review we highlight novel aspects of diagnostic imaging in gynaecological cancers, the paradigm shift in the surgical management of certain female pelvic cancers, as well as potential new molecular targeted therapies. In the last decade, ultra-radical surgery has been shown to increase survival in advanced ovarian cancer (OVC) when extended surgical procedures are included during primary cytoreductive surgery or at interval debulking procedures after neoadjuvant chemotherapy. In cervical cancer (CVC) and endometrial cancer (EMC) endoscopic (laparoscopic or robotic) operations have been shown to significantly reduce the morbidity without altering the cancer-related survival. Although the sentinel lymph node concept is already established in early-stage vulvar cancer, its diagnostic accuracy in EMC and CVC is still under debate. Novel molecular targeted therapies including blocking agents against new blood vessel formation (anti-angiogenesis) and polyadenosine diphosphate ribose polymerase inhibitors have been shown to prolong the progression-free survival in advanced OVC. Other molecular therapies, single or combined, are under investigation in OVC and EMC.
 
M Dal Bo et al.
Chronic lymphocytic leukaemia (CLL) is a clinically heterogeneous disease characterised by the accumulation/expansion of a clonal population of neoplastic cells with the morphological appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. Stimulation through the B cell receptor (BCR) plays a prominent role in the selection and expansion of the malignant clone in CLL. On the other hand, other external signals delivered by several cell types including T lymphocytes, macrophages, stromal cells, endothelial cells, and follicular dendritic cells, operating through either direct BCR-independent cell-cell contact or indirect production of paracrine soluble factors, synergistically cooperate in regulating proliferation and survival of CLL cells. In this context, CD49d is known to play a pivotal role in mediating both cell-cell and cell-matrix interactions in CLL-involved tissues, eventually delivering pro-survival signals and protecting CLL cells from drug-induced damages. In the present review, we focused on functional and physical interactions of CD49d with other microenvironmental receptors, including CD38 and BCR, and other specific CD49d-dependent interactions in lymph node and bone marrow microenvironments responsible for growth and survival-supporting signals, eventually influencing CLL prognosis and therapeutic options.
 
 

News Updates
 

 

Are YOU at Increased Risk of Leukaemia?

 
“By studying this mutation, we should be able to gather a better understanding of how leukaemia develops.”
 

 

 

Rise in Deadly Skin Cancer is by No Means Old News

 

 

“It is worrying to see melanoma rates increasing at such a fast pace, and across all age groups. It is very important for people to take care of their skin in the sun.”

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What’s Happening in EMJ: Oncology/Hematology
 
Our team is hard at work putting together the next editions of the EMJ Oncology and EMJ HematologyeJournals. As always, we will be working with some of the keenest minds in medicine to produce innovative, state-of-the-art content. If you would like to keep up to date with all of our projects then please do not hesitate to visit the EMJ website. You can also follow us on a number of major social media platforms, including Facebook, Twitter, and LinkedIn.

 

 

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European Society for Medical Oncology (ESMO) Academy 2015

28th-30th August 2015

Oxford, United Kingdom

 

 

 

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European Medical Journal 

 

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