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Men who choose active surveillance instead of radiotherapy or surgery for low-risk prostate cancer have similar Quality of Life as men without cancer Версия для печати Отправить на e-mail

Embargo until: Mon 14th Mar 00.01 (CET; Munich)

Choosing ongoing monitoring instead of immediate curative treatment (surgery or radiotherapy) leads to a better overall quality of life for men with low-risk prostate cancer. In fact, the Quality of life (QoL) is about the same as for men who do not have cancer. These are the findings of a new long-term study comparing Active Surveillance, immediate curative treatment, and a reference group of men without cancer, presented at the European Association of Urology Congress in Munich

Prostate cancer is the most common male cancer, with around 400,000 new cases every year in Europe*. Most patients are treated quickly by surgery -radical prostatectomy (RP) – or radiotherapy (RT), but both treatments can show significant and distressing side effects, most commonly incontinence, or erectile dysfunction. One alternative which is increasingly considered for patients with less-aggressive cancers is to delay or avoid initial treatment, but instead keeping the patient under Active Surveillance (AS), meaning that the cancer is regularly monitored, with the option of switching to curative treatment if the condition of the tumour changes. Now a new study has examined whether AS actually helps prostate cancer patients to live a better quality of life in the long term.

Detailed questionnaires** followed the quality of life of 427 patients (out of the 628 originally contacted), aged between 66-69 who were diagnosed with low-risk prostate cancer and were followed up for between 5 and 10 years after initial diagnosis. 121 of the patients chose active surveillance, whereas 74 had surgery and 232 had radiotherapy. A reference group of 204 men of the same ages who didn’t suffer from prostate cancer were also studied.

They found that those patients on active surveillance reported significantly higher QoL scores than those who had undergone surgery (RP). The AS group reported better urinary function (100 vs. 83, p= <0.001), less urinary incontinence (100 vs. 75, p= <0.001) and better sexual function (44 vs. 6, p= <0.001) than men who underwent RP. When comparing AS with radiotherapy, they found that AS gave a significantly higher sexual satisfaction score (44 vs. 18, p= 0.001). Overall, the QoL of men on AS was very similar to that of men without prostate cancer (p>0.05, meaning no statistical difference).

Dr Lionne Venderbos, of the department of Urology, Erasmus University Medical Center (Rotterdam) who led the research commented:

This is the first study to look at long-term outcomes in these four different groups. We found that men on active surveillance experienced better prostate-related health than men who underwent radical prostatectomy and radiotherapy. This showed up as better urinary function, less urinary incontinence and better sexual function. Furthermore, we found that the quality of life of men on active surveillance was similar to a group of men without prostate cancer. This is interesting because men on active surveillance still live with untreated cancer as compared to men in the reference group who do not have cancer. The monitoring combined with information on the low-risk nature of men their disease may partly explain the similar quality of life.

When choosing treatment, it is important that men think about the potential side-effects that are related to immediate curative treatment, like becoming incontinent or losing the ability to have an erection. When considering active surveillance they should try to imagine whether living with untreated cancer would cause any stress, or that the follow-up visits lead to stress instead of reassurance. Balancing the advantages and disadvantages per type of treatment, will make that a man chooses that type of treatment that fits his wishes and preferences best.

Commenting Dr Alberto Briganti (Milano),Section Editor of European Urology Focus and member of EAU Scientific Congress Committee, said:

This is an interesting study which corroborates the notion that active surveillance is not only safe but well accepted by patients as possible initial management of low risk prostate cancer. While we could have been anticipated overall lower sexual and urinary function in men treated with surgery or radiation therapy as compared to men receiving AS, it is interesting to note that long-term quality of life of men on AS was comparable to that of men without prostate cancer. Proper patient counseling about safety of AS is key to maintain both good quality of life, and intact psychological and functional well-being over time. We also need to note that it is possible that patients choosing AS may be less disposed to accept any form of treatment, and this might be difficult to uncover via the retrospective comparisons of validated questionnaires. “

This work was supported by the Prostate Cancer Research Foundation (SWOP), Rotterdam, The Netherlands.

Notes for Editors



Dr Lionne Venderbos Этот адрес e-mail защищен от спам-ботов. Чтобы увидеть его, у Вас должен быть включен Java-Script

Dr Alberto Briganti Этот адрес e-mail защищен от спам-ботов. Чтобы увидеть его, у Вас должен быть включен Java-Script

EAU Press Officer, Tom Parkhill:  Этот адрес e-mail защищен от спам-ботов. Чтобы увидеть его, у Вас должен быть включен Java-Script  telephone +39 349 238 8191

The 16th European Association of Urology conference takes place in Munich from 11th to 15thth March. This is the largest and most important urology congress in Europe, with up to 13,000 expected to attend. Conference website

*see for statistics

** . Validated translations of the SF-12, EQ-VAS, STAI-6 and EPIC questionnaires were used. For the active surveillance group, the MAX-PC was included as well.

Abstract 949

Long-term quality of life outcomes after active surveillance or curative treatment for prostate cancer

Author list Venderbos, L.D.F.1, Aluwini, S.A.2, Roobol, M.J.1, Bokhorst, L.P.1, Oomens, E.H.G.M.3, Bangma, C.H.1, Korfage, I.J.4

1Erasmus MC, Dept. of Urology, Rotterdam, Netherlands, The, 2Erasmus MC, Dept. of Radiology, Rotterdam, Netherlands, The, 3Amphia Hospital, Dept. of Urology, Breda, Netherlands, The, 4Erasmus MC, Dept. of Public Health, Rotterdam, Netherlands, The

Introduction & Objectives Long-term, i.e. 5-10 year, quality of life (QoL) data in men on active surveillance (AS) is scarce. We compared long-term QoL between men on AS, men who underwent radical prostatectomy (RP) or radiotherapy (RT), and a reference group of men without prostate cancer (PCa).

Material & Methods Four groups were invited to fill in a one-time QoL questionnaire; (1) men following a structured AS protocol (PRIAS), (2) men who underwent RP between 2007-2011 in the context of a screening study (ERSPC Rotterdam); (3) men who underwent RT at the Erasmus Medical Center, Rotterdam, and (4) a reference group of men without prostate cancer who were age matched to the AS, RP, and RT groups. Follow-up in treatment groups was ≥ 4 years. The questionnaire addressed general health (SF-12), respondents’ self-rated health (EQ-VAS), generic anxiety (STAI-6), PCa-related anxiety (MAX-PC, for AS only), and urinary, bowel and sexual function (EPIC). Statistical significance (p≤0.05) and clinical relevance (Minimal Important Difference (MID), ≥0.5 SD) of differences in questionnaire scores between groups were assessed.

Results Response rates for the AS, RP, RT and reference group amounted to 73% (121/166), 67% (74/111), 67%(232/348), and 75% (204/273) respectively. Median ages of men ranged from 73 to 76. Men on AS were more often highly educated (table 1). More men on AS were still employed, which is likely related to age. The AS group reported better urinary function (100 vs. 83, p= <0.001), less urinary incontinence (100 vs. 75, p= <0.001) and better sexual function (44 vs. 6, p= <0.001) than men who underwent RP. These differences were also clinically relevant. When comparing AS to RT a statistically significant and clinically relevant difference in favor of the AS group was seen regarding sexual function (44 vs. 18, p= 0.001). The QoL of men on AS was very similar to that of men without PCa.

Conclusions In the long-term, QoL of men on AS was better than that of men who underwent direct active treatment and similar to that of men without PCa. Furthermore, anxiety-levels are low for men that choose to follow an AS strategy for a median of 6.5 years. This is important information for urologists and for newly diagnosed men with low-risk PCa, facing a decision about their initial therapy.

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